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KMID : 1134820150440020260
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Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 2 p.260 ~ p.267
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Quality Properties of Enteric-Coated Soft Capsule Using PEG as a Plasticizer
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Yang Joo-Hwan
Han Joon-Taek
Oh In-Ho
Park Geum-Duck
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Abstract
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We investigated the applicability of polyethylene glycol (PEG) as a plasticizer in enteric-coated soft capsules based on determination of quality characteristics according to molecular weight and concentration of enteric-coating PEG solution. There was no difference according to molecular weight of PEG, whereas a low PEG concentration in the enteric-coating solution was associated with higher whiteness index and slower disintegration time in pH 6.8 media. Brittleness was observed in the coating film at seam areas in 5% PEG enteric-coating solution after 2 weeks of storage at room temperature. The enteric-coating properties of PEG were compared with those of acetylated monoglyceride (AMG) and triacetin, which are enteric-coating plasticizers. Enteric-coated soft capsule containing PEG as a plasticizer showed a lower whiteness index and faster dissolution profile than AMG and triacetin. Moreover, enteric-coated soft capsule containing AMG and triacetin as plasticizers showed coating film brittleness at seam areas after 2 months of accelerated storage [40°C, relative humidity (RH) 75%] but no difference at room temperature storage (25°C, RH 60%). The present study suggests that concentration of PEG is important to determine enteric-coating quality, regardless of the molecular weight of PEG. In conclusion, PEG has potential as a plasticizer due to its transparency and storage stability in enteric-coated soft capsules.
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KEYWORD
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enteric-coated soft capsule, polyethylene glycol, plasticizer
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